Now Accepting Letters of Intent

REACH Network Pilot Research Program

Pilot awards of up to $32,500 for one-year complementary and integrative health research projects at REACH partner institutions. Full applications are due November 30, 2026. Learn more and apply LOIs due Oct 15, 2026

Practice-Based Research (PBR) Pilot Grants

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Other
Practice-based research (PBR) is clinical investigation grounded in the outcomes of real-world care, drawing from data already collected during integrative health visits. With support from the Krupp Endowed Fund, UC San Diego Centers for Integrative Health uses PBR to evaluate the impact of its integrative medicine clinical programs and services. Pilot grants for in-kind research support are available each year.

Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)

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Application due dates
R01
Supports research on strategies to disseminate and implement evidence-based health interventions in real-world settings. Projects may examine methods to improve adoption, integration, sustainability, and impact of interventions across healthcare systems and communities.

Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)

Off
Application due dates
R21
Supports research on strategies to disseminate and implement evidence-based health interventions in real-world settings. Projects may examine methods to improve adoption, integration, sustainability, and impact of interventions across healthcare systems and communities.

Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Mind and Body Interventions

Application due dates
U24
Supports coordinating centers that provide infrastructure and operational support for multi-site clinical trials of mind–body interventions. Coordinating centers help manage study design, data coordination, quality control, and collaboration across trial sites.

Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)

Off
Application due dates
R01
Supports research on strategies to disseminate and implement evidence-based health interventions in real-world settings. Projects may examine methods to improve adoption, integration, sustainability, and impact of interventions across healthcare systems and communities.

Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)

Off
Application due dates
R21
Supports research on strategies to disseminate and implement evidence-based health interventions in real-world settings. Projects may examine methods to improve adoption, integration, sustainability, and impact of interventions across healthcare systems and communities.

Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Mind and Body Interventions

Application due dates
U24
Supports coordinating centers that provide infrastructure and operational support for multi-site clinical trials of mind–body interventions. Coordinating centers help manage study design, data coordination, quality control, and collaboration across trial sites.

Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)

Off
Application due dates
R01
Supports research on strategies to disseminate and implement evidence-based health interventions in real-world settings. Projects may examine methods to improve adoption, integration, sustainability, and impact of interventions across healthcare systems and communities.

Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)

Off
Application due dates
R21
Supports research on strategies to disseminate and implement evidence-based health interventions in real-world settings. Projects may examine methods to improve adoption, integration, sustainability, and impact of interventions across healthcare systems and communities.

PCORI Cycle 1 2027 Funding Announcements

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Application due dates
Other
Funds comparative effectiveness research with strong patient and stakeholder engagement, including Broad Pragmatic Studies (up to $12 million in direct costs), Phased Large Awards for Comparative Effectiveness Research, and Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research. Head-to-head questions about CIH approaches, including digitally delivered interventions, may be a good fit. Letters of Intent are due January 6, 2027; full applications are due May 4, 2027.

Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)

Off
Application due dates
R01
Supports research on strategies to disseminate and implement evidence-based health interventions in real-world settings. Projects may examine methods to improve adoption, integration, sustainability, and impact of interventions across healthcare systems and communities.

NIH Parent R01 (NCCIH as Assigned Institute)

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Application due dates
R01
For investigator-initiated projects that don't fit a targeted funding announcement, the parent R01 remains a strong option, with NCCIH as the assigned institute for complementary and integrative health research. New applications are due February 5, June 5, and October 5 each year; resubmissions are due one month later.

Mind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms (R61/R33 Clinical Trial Required)

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Application due dates
Other
Supports mechanistic clinical trials of mind and body interventions such as mindfulness meditation, yoga, acupuncture, and massage, with emotional well-being mechanisms as the primary outcome and the Whole Person Health Index as a secondary outcome. The phased R61/R33 design funds a feasibility phase first, followed by the full-scale trial once R61 milestones are met.

Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)

Off
Application due dates
R21
Supports research on strategies to disseminate and implement evidence-based health interventions in real-world settings. Projects may examine methods to improve adoption, integration, sustainability, and impact of interventions across healthcare systems and communities.

PCORI Cycle 1 2027 Funding Announcements

Off
Application due dates
Other
Funds comparative effectiveness research with strong patient and stakeholder engagement, including Broad Pragmatic Studies (up to $12 million in direct costs), Phased Large Awards for Comparative Effectiveness Research, and Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research. Head-to-head questions about CIH approaches, including digitally delivered interventions, may be a good fit. Letters of Intent are due January 6, 2027; full applications are due May 4, 2027.

Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)

Off
Application due dates
R01
Supports research on strategies to disseminate and implement evidence-based health interventions in real-world settings. Projects may examine methods to improve adoption, integration, sustainability, and impact of interventions across healthcare systems and communities.

NIH Parent R01 (NCCIH as Assigned Institute)

Off
Application due dates
R01
For investigator-initiated projects that don't fit a targeted funding announcement, the parent R01 remains a strong option, with NCCIH as the assigned institute for complementary and integrative health research. New applications are due February 5, June 5, and October 5 each year; resubmissions are due one month later.

Mind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms (R61/R33 Clinical Trial Required)

Off
Application due dates
Other
Supports mechanistic clinical trials of mind and body interventions such as mindfulness meditation, yoga, acupuncture, and massage, with emotional well-being mechanisms as the primary outcome and the Whole Person Health Index as a secondary outcome. The phased R61/R33 design funds a feasibility phase first, followed by the full-scale trial once R61 milestones are met.

Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)

Off
Application due dates
R21
Supports research on strategies to disseminate and implement evidence-based health interventions in real-world settings. Projects may examine methods to improve adoption, integration, sustainability, and impact of interventions across healthcare systems and communities.

NIH Parent R01 (NCCIH as Assigned Institute)

Off
Application due dates
R01
For investigator-initiated projects that don't fit a targeted funding announcement, the parent R01 remains a strong option, with NCCIH as the assigned institute for complementary and integrative health research. New applications are due February 5, June 5, and October 5 each year; resubmissions are due one month later.

Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)

Off
Application due dates
R01
Supports research on strategies to disseminate and implement evidence-based health interventions in real-world settings. Projects may examine methods to improve adoption, integration, sustainability, and impact of interventions across healthcare systems and communities.

Mind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms (R61/R33 Clinical Trial Required)

Off
Application due dates
Other
Supports mechanistic clinical trials of mind and body interventions such as mindfulness meditation, yoga, acupuncture, and massage, with emotional well-being mechanisms as the primary outcome and the Whole Person Health Index as a secondary outcome. The phased R61/R33 design funds a feasibility phase first, followed by the full-scale trial once R61 milestones are met.

Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)

Off
Application due dates
R21
Supports research on strategies to disseminate and implement evidence-based health interventions in real-world settings. Projects may examine methods to improve adoption, integration, sustainability, and impact of interventions across healthcare systems and communities.

Mind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms (R61/R33 Clinical Trial Required)

Off
Application due dates
Other
Supports mechanistic clinical trials of mind and body interventions such as mindfulness meditation, yoga, acupuncture, and massage, with emotional well-being mechanisms as the primary outcome and the Whole Person Health Index as a secondary outcome. The phased R61/R33 design funds a feasibility phase first, followed by the full-scale trial once R61 milestones are met.

Mind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms (R61/R33 Clinical Trial Required)

Off
Application due dates
Other
Supports mechanistic clinical trials of mind and body interventions such as mindfulness meditation, yoga, acupuncture, and massage, with emotional well-being mechanisms as the primary outcome and the Whole Person Health Index as a secondary outcome. The phased R61/R33 design funds a feasibility phase first, followed by the full-scale trial once R61 milestones are met.