PCORI Cycle 1 2027 Funding Announcements

Funds comparative effectiveness research with strong patient and stakeholder engagement, including Broad Pragmatic Studies (up to $12 million in direct costs), Phased Large Awards for Comparative Effectiveness Research, and Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research. Head-to-head questions about CIH approaches, including digitally delivered interventions, may be a good fit. Letters of Intent are due January 6, 2027; full applications are due May 4, 2027.